What is the difference between nattokinase and lumbrokinase?

When exploring natural enzyme supplements for cardiovascular health, two names frequently emerge: nattokinase and lumbrokinase. Both are fibrinolytic enzymes known for their blood-thinning properties, but they come from entirely different sources and have distinct characteristics. Understanding these differences can help you make an informed decision about which enzyme supplement might be right for your wellness journey.

Understanding Nattokinase: The Japanese Enzyme

Nattokinase is a powerful enzyme extracted from natto, a traditional Japanese fermented soybean dish that has been consumed for over 1,000 years. This premium Japanese enzyme is produced when soybeans are fermented with the beneficial bacteria Bacillus subtilis var. natto. The resulting enzyme has been extensively studied for its cardiovascular benefits and natural blood-thinning properties.

Key characteristics of nattokinase include:

• Natural origin: Derived from fermented soybeans, making it a plant-based enzyme suitable for vegans
• Proven tradition: Used in Japanese culture for centuries as part of their heart-healthy diet
• Standardized potency: Measured in Fibrinolytic Units (FU), with quality supplements typically containing 2000-4000 FU per serving
• Gentle on the system: Generally well-tolerated and can be taken morning or night
• Research-backed: Extensive studies support its benefits for blood pressure, cholesterol, and arterial plaque

Understanding Lumbrokinase: The Earthworm Enzyme

Lumbrokinase, on the other hand, is derived from earthworms - specifically from the digestive enzymes of the Lumbricus rubellus species. This enzyme complex has been used in Traditional Chinese Medicine for centuries and contains multiple fibrinolytic enzymes that work synergistically.

Key characteristics of lumbrokinase include:

• Animal origin: Extracted from earthworms, making it unsuitable for vegetarians and vegans
• Enzyme complex: Contains multiple enzymes rather than a single purified enzyme
• Potent activity: Generally considered more potent than nattokinase in laboratory studies
• Traditional use: Long history in Chinese medicine for circulatory support
• Limited availability: Less commonly found in supplement form compared to nattokinase

Key Differences Between Nattokinase and Lumbrokinase

Source and Dietary Compatibility

The most obvious difference lies in their origins. Nattokinase comes from fermented soybeans, making it ideal for those following plant-based diets, while lumbrokinase is derived from earthworms. This makes nattokinase the clear choice for vegans and vegetarians seeking natural blood thinner alternatives.

Research and Clinical Evidence

Nattokinase boasts more extensive human clinical research, with studies demonstrating its effects on blood pressure, arterial plaque, and cholesterol levels. The NIH has documented numerous studies on nattokinase benefits, while lumbrokinase research is primarily limited to laboratory and animal studies.

Availability and Quality Control

High-quality nattokinase supplements are more readily available, with standardized potency measurements and third-party testing common among reputable manufacturers. Premium formulations, like those made in FDA-registered facilities in the USA, ensure consistent quality and purity.

Safety Profile and Side Effects

Both enzymes have natural blood-thinning properties, but nattokinase has a longer track record of safe use in humans. Its gentle nature makes it suitable for daily wellness routines, whether taken before bed or as part of morning supplementation.

Which Enzyme Is Right for You?

For most people seeking natural circulation support, nattokinase offers several advantages:

• Established safety profile with centuries of traditional use
• Extensive clinical research supporting its cardiovascular benefits
• Vegan-friendly formula suitable for all dietary preferences
• Standardized potency ensuring consistent results
• Wide availability in high-quality, organic formulations

When choosing a nattokinase supplement, look for products that offer premium Japanese enzyme extraction, are free from stearates and artificial additives, and are manufactured in FDA-registered facilities. Quality nattokinase supplements should provide clear FU measurements and undergo third-party testing for purity and potency.

Supporting Your Cardiovascular Wellness Journey

Whether you're exploring nattokinase for blood pressure support, as a natural alternative to synthetic blood thinners, or as part of a comprehensive cardiovascular wellness routine, understanding these enzyme differences helps you make informed decisions. Consider consulting with healthcare professionals familiar with enzyme therapy to determine the best approach for your individual needs.

The choice between nattokinase and lumbrokinase often comes down to personal preferences, dietary restrictions, and availability of high-quality products. With its rich tradition, extensive research, and clean formulation options, nattokinase continues to be the preferred choice for those seeking natural enzyme support for their cardiovascular health.